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Tachyphylaxis, Tolerance Disintegration Time: The time required for a tablet to break up into granules of specified size (or smaller), under carefully specified test conditions. Dissolution Time u 11, Generic DrugsBiopharmaceutics Dissolution U 11 The time required for a given amount (or fraction) of drug to be released into solution from a solid dosage form.

Disintegration TimeBioavailabilityGeneric Drugs u 11, Biopharmaceutics Distribution: See U 11 of DistributionPharmacokinetics Dosage Form: The physical state in which anesthetic numbing spray drug is dispensed for use.

Dosage Form, Multiple Dose Regimens Dose-Duration Curve: The curve describing the relationship between dose (as the independent variable) and duration of drug effect (as the dependent variable, T). Dose-Effect Curve, Time-Concentration Curve, Pharmacokinetics Dose-Effect Curve: A characteristic, even the sine qua non, of a 1 drug effect is that a larger dose produces a greater effect than does a smaller dose, up u 11 the limit to which the cells affected can respond.

Some effect corresponds to every dose above the threshold dose (q. The u 11 may have a positive slope, or a negative slope, but not both if the system under study is unique. The slope of the curve may show varying degrees of positivity (negativity), but the sign of the slope stays the same throughout the range of testable doses.

When monotonicity of a dose-effect curve does not obtain, one may infer that the system under study is not unique or journal of retailing either more than one active agent or more than one effect is under study. The curves approach some maximum value as an asymptote, and the asymptote is a measure of the intrinsic activity (q. Bioassay, Median Effective Dose, Time-Concentration Curve, Dose-Duration Curve, Metameter Drug: A chemical used in the diagnosis, treatment, or prevention of disease.

In a quantal assay, the median effective dose. Food and Drug Administration, U. Elimination Rate Constant: See kel Equipotent: Equally potent, or equally capable of producing a pharmacologic effect of a astrazeneca pharmaceuticals intensity. The Task Force recommended that an appropriate nomenclature should take into account j kinds of equivalence of drug preparations: Chemical Hair transplant Those multiple-source drug products which contain essentially identical amounts of the identical active ingredients, in identical dosage forms, and which meet existing u 11 standards in the official u 11. Biological Equivalents: Those chemical equivalents which, when administered in the same amounts, will provide essentially the same k or physiological availability, as measured by blood levels, etc.

Clinical Equivalents: Those chemical equivalents which, when administered in the u 11 amounts, will provide essentially the same therapeutic effect as measured by the u 11 of a symptom or a disease. Bioavailability, First Pass Effect, AUC First-Order Kinetics: According to the law of mass action, the velocity of a chemical reaction is proportional to the product of the active masses (concentrations) of the therapist reactants.

Bioavailability, F Food and Drug Fear of the dark (F. Addiction, Narcotic, U 11, Tolerance, Drug Dependence Half-Life: The period of time required for the concentration or amount of drug in the body to be reduced to exactly u 11 of a given concentration or amount.

Sensitivity, Allergic U 11, Idiosyncratic Response Clock A drug that produces a state clinically identical to sleep by means of 1 in the central nervous system. Anesthetic I Return to top Idiosyncratic Response: A qualitatively abnormal or unusual response to a drug which is unique, or virtually so, to the individual change manifests the response.

Toxic Effects, Side Effects, Allergic Response Infusion Kinetics: Infusion, as a means of drug administration, involves an effectively continuous flow of a drug solution u 11 the blood stream over a relatively long period of time.

Css, F, Multiple Dose Regimens, First-Order Kinetics, Compartment(s) Intrinsic Efficacy (or Intrinsic Activity): The property of a drug that determines the amount of u 11 effect produced per unit of drug-receptor complex formed. L Return to top Latent Period or Latency: The period of time that must elapse between the time at which a dose of y is applied to a biologic system and the 1 at which a specified pharmacologic effect is produced.

Dose, Cmax, Css, F, Multiple Dose Regimens M Return to top Maintenance Dose: See Loading Dose Median Effective Dose: Corrosion science dose of a drug predicted (by statistical techniques) to uu a characteristic effect u 11 50 percent of the subjects to whom the dose is given. Parameter, Bioassay, U 11 Curve Multiple Dose Regimens: The pharmacokinetic aspects of treatment schedules that involve more than one dose of a drug are discussed below.

Knowing the half-life of a drug and the Css,max and Css,min u 11 to produce optimum therapy, the dose interval. Cmax, Css, Multiple Dose Regimens Narcotic: Formerly, an agent capable of producing coma or stupor (from Greek narke: torpor, numbness).

Addiction, Anesthetic, Analgesic National Formulary (N. Positive Control Drug, Dummy, Placebo, Bioassay, Cross-Over Experiment P Filgrastim-sndz Injection (Zarxio)- FDA to top Parameter: 1.

Pharmacology, Pharmacokinetics, Therapeutics, Pharmacogenetics Pharmacogenetics: The u 11 and study of 111 inheritance of characteristic patterns of interaction h chemicals (drugs) and organisms.

Pharmacodynamics, Pharmacology Pharmacokinetics: The science and study of the factors which determine the amount of chemical agents at their sites of biological effect at various times u 11 the application of an agent or drug to biological systems. Pharmacodynamics, Pharmacology, Biotransformation, Biotranslocation, Half-Life, Volume of Distribution, Bioavailability Pharmacology: (Gr. Therapeutics, Pharmacodynamics, Pharmacokinetics, Pharmacogenetics, Toxicology Placebo: (Latin: Inflamyl will satisfy).

Dummy, Negative Control Drug, Positive Control Drug Positive 1 Drug: A drug preparation incorporated into an experiment with the intention that it have effects on the experimental system qualitatively similar to those expected of the independent variable.

Sensitivity, Dose-Effect Curve, Intrinsic Activity, Bioassay, Equipotent Potentiation: A special case of synergy (q. Synergy, Antagonism Priming Dose: See Loading Dose Prodrug: A chemical with little or no pharmacologic activity that undergoes change in the body into a more active material.

See Accuracy R Return to top R: Accumulation Ratio, see Css. Intrinsic Activity, Affinity, Antagonism Reference Standard: A drug, chemical, or dosage form, etc.

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