Journal of bodywork movement therapies

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Start reading on Scribd We use your LinkedIn profile and activity data to personalize ads and to show you more relevant ads. You can change your ad preferences anytime. Pharmacokinetics is the q. The ionization of drugs may markedly redu. Route of administration: Topical: De. Intravenous administration has no absorption phase According to the rate of. Distribution of Drugs It is the passage of drug from the circulation to the tissue and site of its action.

BBB is lipoidal and limits the entry of non-lipid soluble drugs (amikacin, gent. Chemical alteration of the drug in the body Aim: to convert non-pol. Similarly amides and p. Cyclization: is formation of ring structure from a straight chain compound, e. Acetylation: Compounds having amino or hydrazine residues are conjugated with the he. Methylation: The amines and phenols can be methylated. Methionine and cysteine act a. Sign up for a Scribd free trial to download now.

Also pf for Post Graduate students of Pharmacology and Pharmaceutical Sciences. A power point presentation on general aspects bodyworkk Pharmacokinetics suitable for undergraduate medical students beginning to study Pharmacology. The SlideShare family just got bigger. Download with free trial Like this presentation.

Pharmacokinetics ppt by NITISH SHAH 128332 views Pharmacokinetics by Lawrence Journal of bodywork movement therapies 65923 views Drug excretion lecture 10 by homebwoi 62212 bodywkrk Excretion of drug (VK) by Dr. Amen Joournal Human: The Bulletproof Plan to Age Backward and Maybe Even Live Forever Dave Asprey The Vagina Bible: The Vulva and the Vagina: Separating the Myth from the Medicine Jen Gunter Breasts: The Owner's Manual: Every Woman's Guide therapjes Reducing Cancer Risk, Making Treatment Choices, and Optimizing Outcomes Kristi Funk Why We Sleep: Unlocking the Power of Sleep and Dreams Matthew Walker Men Are from Mars, Women Are from Venus: The Classic Guide to Understanding the Opposite Sex John Gray Maybe You Should Talk to Someone: A Journal of bodywork movement therapies, HER Therapist, and Our Lives Revealed Lori Gottlieb Related Audiobooks Free with a 30 day trial from Scribd The Awe Factor: How a Little Bit of Wonder Can Make a Big Difference in Your Life Allen Klein The Energy Paradox: What bodtwork Do When Your Get-Up-and-Go Has Got Up and Gone Steven R.

Levy To Raise A Boy: Classrooms, Locker Rooms, Bedrooms, and the Hidden Struggles of American Boyhood Emma Brown Single On Purpose: Redefine Everything. Brahma Department of Pharmacology NEIGRIHMS, Shillong how the therapiea body act. What is Pharmacokinetics how the human body act on the drugs. Pharmacokinetics is the quantitative study of drug movement post surgery depression, through and out of the body.

Intensity of effect is related to concentration of the drug at the site of action, which depends on its pharmacokinetic properties Pharmacokinetic properties of particular drug is important to determine the route of administration, dose, onset of action, peak movemenf time, duration of action and frequency of dosing 3. The Pharmacokinetic Process 5. The Pharmacokinetic Bodywotk 6. Biological Membrane - image Drug molecules can cross cell m. Passive transport (down hill movement) Most important Mechanism for most of the Drugs Majority of drugs diffuses across the membrane in the direction of concentration gradient No active role of the membrane Proportional to lipid : water partition coefficient Lipid soluble drugs diffuse by dissolving in the lipoidal matrix of the membrane Characteristics Not requiring energy Having no saturation Having no carriers Not resisting competitive inhibition Affecting factors thearpies 9.

Passive transport Affecting factors : the size of molecule lipid solubility polarity degree of ionization the PH of the environment such as: fluid of body fluid in cell blood, urine The drugs which are Unionized, low polarit. Remember The drugs which uournal Unionized, low polarity and higher lipid solubility are easy to permeate membrane.

The drugs which are ionized, high polarity and lower lipid solubility are difficult to permeate membrane. Most of drugs are weak boeywork or weak base.

The ionization of drugs may markedly coltalin their ability to permeate membranes. The degree of ionization of drugs is determined by the surrounding pH and their pKa. Filtration Involve specific membran. Specific, saturable and inhibitable Depending therapiess Energy requirement - Can be either Facilitated (passive) or Active Transport Move substrate of a singl. Facilitative transporters Move substrate of a single class (uniporters) down a concentration gradient No energy dependent Similar to entry of glucose into 500mg (GLUT 4) Active (concen.

ATP hydrolysis) Secondary transporters - utilize energy stored in Tetanus and Diphtheria Toxoids Adsorbed (Tenivac)- Multum and ion gradients generated by a primary active transporter (e.

Pinocytosis It involves the invagination of a part of the cell membrane and trapping within the cell joirnal a small vesicle containing extra therpies constituents. The vesicle contents can than be released within movemwnt cell, or extruded from the journal of bodywork movement therapies side of the cell. Pinocytosis is important for the transport of some macromolecules (e. Absorption is the transfer o.

Absorption journal of bodywork movement therapies Drugs Absorption is the transfer of a drug from its site of administration to the blood stream Most of drugs are absorbed by the way of passive transport Intravenous administration has no absorption Fraction of administered dose and rate movemeht absorption are important Drug properties:.

Factors affecting absorption Drug properties: lipid solubility, molecular weight, and polarity etc Blood flow to the absorption site Total surface area available for absorption Journal of bodywork movement therapies time at the movemnet surface Affinity with special tissue Routes journal of bodywork movement therapies Administration (important): Route of admi.

As a Result, the concentration of drug in the jounral circulation will be reduced. Bioavailability Bodywwork refers to the rate and extent journal of bodywork movement therapies absorption of a drug from dosage form as determined by its concentration-time curve in blood or by its excretion in urine. It is a measure of the fraction (F) of administered dose of mkvement drug that reaches the systemic circulation in the unchanged form Bioavailability of drug injected journal of bodywork movement therapies. MTC MEC It is the passage of drug.

The extent of distribution of drug depends jlurnal its lipid solubility, ionization at physiological pH (dependent on pKa), extent of binding to plasma and tissue proteins and differences in regional blood flow, disease like CHF, uremia, cirrhosis Movement of drug - until journal of bodywork movement therapies between unbound drug in plasma and tissue fluids Definition: Apparent Vol.

Blood brain barrier (BBB) : includes the capillary endothelial cells (which have tight junctions and lack large intracellular pores) and an investment of glial tissue, over the capillaries. A similar barrier is loctated in the choroid plexus Brain and CSF Penetration BBB is lipoidal. BBB is lipoidal and limits the entry of non-lipid soluble drugs (amikacin, gentamicin, neostigmine etc.

This is used latter in parkinsonism. Only lipid soluble Drugs can pen. Plasma Protein Binding Plasma protein binding journal of bodywork movement therapies Most drugs possess physicochemical affinity for plasma proteins.



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