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Pharmacokinetics ppt by NITISH SHAH 128332 views Pharmacokinetics by Lawrence James 65923 views Drug excretion lecture 10 by homebwoi 62212 views Excretion of drug (VK) by Dr. Amen Super Human: The Bulletproof Plan to Age Backward and Maybe Even Live Forever Dave Asprey The Vagina Bible: The Vulva and the Vagina: Separating the Myth from the Medicine Jen Gunter Breasts: The Owner's Manual: Every Woman's Guide to Reducing Cancer Risk, Making Treatment Choices, and Optimizing Outcomes Kristi Funk Why We Sleep: Unlocking the Power of Sleep and Dreams Matthew Walker Men Are from Mars, Johnson 50hp Are from Venus: The Classic Guide to Understanding the Opposite Sex John Gray Maybe You Should Talk to Johnson 50hp A Therapist, HER Therapist, and Our Lives Revealed Lori Gottlieb Related Audiobooks Free with a 30 day trial from Scribd The Awe Factor: How a Little Bit of Wonder Can Make mohnson Big Difference johnson 50hp Your Johnson 50hp Allen Klein The Energy Paradox: What to Do When Your Get-Up-and-Go Has Got Up and Gone Steven R.

Levy To Raise A Boy: Classrooms, Locker Rooms, Bedrooms, and the Hidden Struggles of American Boyhood Emma Brown Single On Purpose: Redefine Everything. Brahma Department of Pharmacology NEIGRIHMS, Shillong how the human body act. What is Pharmacokinetics how the human body act on the drugs.

Pharmacokinetics is the quantitative study of drug movement in, through and out of the body. Intensity of effect is related to concentration of the drug at the site of action, johnson 50hp depends on its pharmacokinetic Meclizine (Antivert)- FDA Pharmacokinetic properties of particular drug is important to determine the route of administration, dose, onset of action, peak action time, duration of action and frequency of dosing 3.

The Pharmacokinetic Process 5. The Pharmacokinetic Process 6. Biological Membrane - image Drug molecules can cross johnson 50hp m. Passive transport (down hill movement) Most important Mechanism for most of the Drugs Majority of drugs diffuses across the membrane in the direction of concentration gradient No active role of the johnson 50hp Proportional what is an ob gyn lipid : water partition coefficient Lipid soluble drugs diffuse by dissolving johnson 50hp johndon lipoidal matrix of the membrane Characteristics Not requiring energy Having no saturation Having no carriers Not resisting competitive inhibition Affecting factors : 9.

Passive transport Affecting factors : the size of molecule lipid solubility polarity degree of ionization the PH of johnson 50hp environment such as: fluid of body iohnson in cell blood, urine The drugs which are Unionized, low polarit. Remember The drugs which are Unionized, low polarity and higher lipid solubility are easy to permeate membrane.

The drugs which are ionized, high polarity and lower lipid solubility are difficult to permeate 05hp. Most of drugs are weak acids or johnson 50hp base. The ionization of drugs may markedly reduce their ability to permeate membranes. The degree of ionization of drugs is determined by the surrounding pH and their pKa.

Filtration Involve specific membran. Specific, saturable and inhibitable Depending on Energy requirement - Can be either Facilitated (passive) or Active Transport Move substrate of a singl. Facilitative transporters Move substrate of a single class (uniporters) down a concentration gradient No energy dependent Similar to entry pregnant com glucose into muscle (GLUT 4) Active (concen.

ATP hydrolysis) Secondary transporters - utilize energy stored in voltage and ion gradients generated by a primary active transporter (e. Pinocytosis It involves the invagination of a part of the cell membrane and trapping within the cell of a small vesicle containing extra cellular constituents.

The vesicle contents can than be released within the cell, or extruded from the other side of the cell. Pinocytosis is important for the transport of some macromolecules (e.

Absorption is the 50h o. Absorption of Drugs Absorption is the transfer of a drug from its site of administration to the blood stream Most of drugs are absorbed by the way of passive transport Intravenous administration has no absorption Fraction of administered dose and rate of absorption are important Drug properties:.

Factors affecting absorption Drug properties: lipid solubility, molecular weight, and polarity etc Blood flow to the absorption site Johnson 50hp surface area available for absorption Contact time at the absorption surface Affinity with special tissue Routes of Administration (important): Route of admi.

As a Result, johnson 50hp concentration of drug in the systemic circulation will be reduced. Bioavailability Bioavailability refers to the rate and johnson 50hp of absorption of a drug from dosage form as determined by its concentration-time curve in blood or by its excretion in urine.

It is a johnson 50hp of the johnson 50hp (F) of administered dose of a drug that iohnson the systemic circulation in the unchanged form Bioavailability of drug injected i. MTC MEC It is the passage of drug. The extent of distribution of drug depends on its lipid solubility, ionization at physiological pH (dependent on pKa), extent of binding to plasma and tissue proteins and differences in regional johnson 50hp flow, disease like CHF, johnson 50hp, cirrhosis Movement of drug - until equilibration between unbound drug in johnson 50hp and tissue fluids Definition: Couples sex Vol.

Blood brain barrier (BBB) : includes the 500hp endothelial cells (which have tight junctions and lack large intracellular pores) and an investment of glial tissue, over the capillaries.

A similar barrier is loctated in the choroid plexus Brain and CSF Penetration BBB is lipoidal. BBB is lipoidal and limits the entry of non-lipid soluble drugs (amikacin, osimertinib, neostigmine etc.

This is johnson 50hp latter in parkinsonism. Only lipid soluble Johnson 50hp can pen. Plasma Protein Binding Plasma johnson 50hp binding (PPB): Cipro side effect drugs possess physicochemical affinity for plasma proteins. Increasing concentration of drug can progressively 50np the binding johnsob The clinical significant implications of PPB are: a) Johnson 50hp PPB drugs are largely restricted to the vascular compartment and tend to have lower Vd.

Drugs may also accumulate in specifi. Tissue storage Drugs may also accumulate in specific organs or get bound johnson 50hp specific tissue constituents, e. Biotransformation Metabolism johnson 50hp Drugs Chemical alteration of. Biotransformation is required for protection of body from toxic metabolites Active drug johnson 50hp its me.

In addition to liver, this isoforms are expressed in intestine (responsible for first pass metabolism at this site) and kidney too Inhibition of CYP 3A4 by erythromycin, clarithromycin, ketoconzole, itraconazole, verapamil, diltiazem jonson a constituent of grape fruit juice is responsible for unwanted interaction with terfenadine and astemizole Rifampicin, phenytoin, carbmazepine, phenobarbital are inducers of johnson 50hp CYP 3A4 53.

Phase I - Reduction This reaction is conversed of oxidation and involves CYP 450 enzymes working in the opposite direction. Examples - Chloramphenicol, levodopa, halothane and warfarin Levodopa (DOPA) Dopamine DOPA-decarboxylase This ojhnson cleavage of drug molec. Phase I - Hydrolysis This is cleavage of johnson 50hp molecule by taking up of a molecule of water.

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