Glyxambi (Empagliflozin and Linagliptin Tablets)- FDA

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Nursing Mothers: There is evidence that phenothiazines are excreted in the breast milk of nursing mothers. Caution should be exercised when prochlorperazine is administered to a nursing woman. The antiemetic action of journal of science and food technology may mask the signs and symptoms of overdosage of other drugs and may obscure the diagnosis and treatment of other conditions such as intestinal obstruction, brain tumor and Reye's syndrome (see Glyxambi (Empagliflozin and Linagliptin Tablets)- FDA. When prochlorperazine is used with cancer chemotherapeutic drugs, vomiting as a sign of the It-Iz of these agents may be obscured by the antiemetic effect of prochlorperazine.

Because Glyxambi (Empagliflozin and Linagliptin Tablets)- FDA may occur, large doses and parenteral administration should be used cautiously in patients with impaired cardiovascular systems.

If hypotension occurs after parenteral or oral dosing, place patient in head-low position with legs raised. Other pressor agents, including epinephrine, should not be used because they may cause a paradoxical further lowering of blood pressure. Aspiration of vomitus has occurred in a few post-surgical patients who have received prochlorperazine as an antiemetic. Although no causal relationship has been established, this possibility should be borne in mind during surgical aftercare. Deep sleep, from which patients can be aroused, and coma have been reported, usually with overdosage.

Although disturbances such as galactorrhea, amenorrhea, gynecomastia and impotence have been reported, the clinical significance of elevated serum prolactin levels is unknown for most patients. An increase in mammary neoplasms has been found in rodents after chronic administration of antipsychotic drugs. Chromosomal aberrations in spermatocytes and abnormal sperm have been demonstrated in rodents treated with certain antipsychotics.

Because phenothiazines may interfere with thermoregulatory mechanisms, use with caution in persons who will be exposed to extreme heat. Phenothiazines can diminish the effect of oral anticoagulants. Phenothiazines can produce alpha-adrenergic blockade. Thiazide diuretics may accentuate the orthostatic hypotension that may occur with pheno-thiazines.

Antihypertensive effects of guanethidine and related compounds may be counteracted when phenothiazines are used concomitantly. Concomitant administration of propranolol with phenothiazines results in increased plasma levels of both drugs. Potentiation of anticonvulsant effects does not occur. The presence of phenothiazines may produce false-positive phenylketonuria (PKU) test results.

Long-Term Therapy: Given the likelihood that some patients exposed chronically to antipsychotics will develop tardive dyskinesia, it is advised that all patients in whom chronic use is contemplated be given, if possible, full information about this risk. Children with acute Glyxambi (Empagliflozin and Linagliptin Tablets)- FDA (e.

In such patients, the drug should be used only under close supervision. As with other phenothiazine derivatives, prochlorperazine should be discontinued at least 48 hours before myelography, should not be resumed for at least 24 hours post-procedure, and should not be used for the control of nausea and vomiting occurring either prior to myelography with Amipaque, or postprocedure. Geriatric Use: Clinical studies of prochlorperazine did not include sufficient numbers of subjects aged 65 Glyxambi (Empagliflozin and Linagliptin Tablets)- FDA over to determine whether elderly subjects respond differently from younger subjects.

Geriatric patients are more sensitive to the side effects of antipsychotics, including prochlorperazine. SYMPTOMS--Primarily involvement of the extrapyramidal mechanism producing some of the dystonic reactions described above. Symptoms of central nervous system depression to the point of somnolence or coma. Agitation and restlessness may also occur. Other possible manifestations include convulsions, EKG changes and cardiac arrhythmias, fever and autonomic reactions such as hypotension, dry mouth and ileus.

TREATMENT--It is important to determine other medications taken by the patient since multiple-dose therapy is common in overdosage situations. Treatment is essentially symptomatic and supportive. Early gastric lavage is helpful.

Keep patient under observation and maintain an open airway, since involvement of what are the indications extrapyramidal mechanism may produce dysphagia and respiratory difficulty in severe overdosage.

Do not attempt to induce emesis because a dystonic reaction of the head or neck may develop that could result in aspiration of vomitus. Extrapyramidal symptoms may be treated with antiparkinsonism drugs, barbiturates or Benedryl. See prescribing information for these products. Care should be taken to avoid increasing respiratory depression.

If administration of a stimulant is desirable, amphetamine, dextroamphetamine or caffeine with sodium benzoate is recommended. Stimulants that may cause sweat cold (e. If hypotension occurs, the standard measures for managing Glyxambi (Empagliflozin and Linagliptin Tablets)- FDA shock Glyxambi (Empagliflozin and Linagliptin Tablets)- FDA be initiated.

If it is desirable to administer a vasoconstrictor, Levophed and Neo-Synephrine are most suitable. Other pressor agents, including epinephrine, are not recommended because phenothiazine derivatives may reverse the usual elevating action of these agents and cause further lowering of blood pressure.

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