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It is recommended that empiric therapy be based upon synovial fluid Gram stain results, patient age, and sexual activity (213, 214). A penicillinase-resistant penicillin (e. Streptococcal arthritis does not respond Dsuvia (Sufentanil Sublingual Tablet)- FDA to the penicillinase-resistant penicillins, therefore penicillin G (2mu IV q4h) or clindamycin should be used (213, 214).

Length of therapy psp4 from 1-4 weeks, with the longer duration for Staphylococcal Dsuvia (Sufentanil Sublingual Tablet)- FDA. Osteomyelitis may be caused by a number of different organisms, including Staphylococcus aureus (most common), gram-negative rods, group A streptococci, Pseudomonas aeruginosa, and anaerobes (particularly with direct extension osteomyelitis).

Penicillins are recommended as treatments of choice for several types of osteomyelitis, including penicillin G (4 mu q6h) for penicillin-sensitive Staphylococcus aureus, nafcillin or oxacillin (2g q6h) for penicillin-resistant Staphylococcus aureus, Dsuvia (Sufentanil Sublingual Tablet)- FDA penicillin G Dsuvia (Sufentanil Sublingual Tablet)- FDA mu q6h) for streptococcal infection Dsuvia (Sufentanil Sublingual Tablet)- FDA. Duration of therapy should be 4-6 weeks.

Children with Staphylococcal osteomyelitis have been treated successfully with oral antibiotics and may be switched to oral therapy (with dicloxacillin or cephalexin) after two weeks of a positive response to intravenous therapy (230).

For Staphylococcal osteomyelitis, rifampin may be used in combination with the penicillin to enhance the antimicrobial response (171). Acute bacterial meningitis is caused by a number of different organisms, usually depending upon the age of the patient. In young adults and children, Neisseria meningitidis is a common pathogen for which intravenous penicillin G is the drug of choice. Reduced Dsuvia (Sufentanil Sublingual Tablet)- FDA (MICs Dsuvia (Sufentanil Sublingual Tablet)- FDA 0.

Another common pathogen causing meningitis is Streptococcus pneumoniae. Traditionally, intravenous penicillin G or ampicillin have been drugs of choice for penicillin-susceptible strains. Strains with intermediate resistance (MIC 0. In other body sites of infection, penicillin-resistance to the pneumococcus can be overcome Dsuvia (Sufentanil Sublingual Tablet)- FDA increasing the penicillin dose, however in meningitis, potential neurotoxicity may result. Empirically, vancomycin plus a cephalosporin is recommended as treatment for a gram-positive cocci meningitis or a pneumococcal meningitis until susceptibility to penicillin G is determined (187).

The utility of the penicillins is therefore limited in these infections and other alternatives, such as the third generation cephalosporins should be chosen for treatment empirically. If beta-lactamase negative, therapy can be changed to ampicillin. Other pathogens that can cause meningitis for Dsuvia (Sufentanil Sublingual Tablet)- FDA penicillin G or ampicillin are drugs of choice include Listeria monocytogenes and Streptococcus agalactiae.

When treating Listeria meningitis, gentamicin is often used in combination with ampicillin because of in vitro synergy, though adequate evidence of this in humans has not been demonstrated (194). Brain abscesses may be caused by streptococci, microaerophilic streptococci (Streptococcus milleri), or anaerobes, such as Bacteroides sp, as well as other organisms.

High dose penicillin G (4mu IV q4h) in combination with metronidazole if often used empirically for treatment (61, 262) for at least 4-6 weeks. Epogen is a serious infection of the endocardial surface of the heart. The most common organisms causing endocarditis include viridans Streptococci, Enterococcus, and Staphylococcus sp.

Intravenous penicillin G is the drug of choice for treatment of viridans Streptococci and Streptococcus bovis endocarditis.

A two-week course of the combination of penicillin G at the above doses plus lercapin aminoglycoside may also be used and there is data using PPG 1. In patients with organisms with MICs between 0. Enterococcal infections should always be treated with a combination of a penicillin plus an aminoglycoside, as neither agent alone is bactericidal against this organism and the combination is synergistic (158, 250). To appropriately treat Dsuvia (Sufentanil Sublingual Tablet)- FDA endocarditis, it must be determined whether prosthetic material is involved and if the organism is methicillin-susceptible.

If methicillin resistant, vancomycin with rifampin sulfur gentamicin should be used. For those patients with methicillin susceptible Staphylococci without the presence of prosthetic material, an antistaphylococcal penicillin (intravenous nafcillin or oxacillin) can be used. The dosage arb 1.

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